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The in vitro and in vivo safety evaluation of lactobacillus acidophilus IDCC 3302
- Bang, Wonyeong;
- Chae, Seung A.;
- Ban, O. Hyun;
- Oh, Sangki;
- Park, Chanmi;
- ... Jung, Younghoon;
- 외 3명
SCOPUS
8초록
As consumption of healthy foods continues to garner remarkable public attention, ensuring probiotic safety has become a priority. In this study, the safety of Lactobacillus acidophilus IDCC 3302 was assessed in vitro and in vivo. L. acidophilus IDCC 3302 showed negative results for hemolytic and β-glucuronidase activities. The whole-genome analysis (WGA) revealed that L. acidophilus IDCC 3302 did not possess antibiotic resistance or virulence genes. The minimal inhibitory concentrations of L. acidophilus IDCC 3302 confirmed its safety concerning antibiotic resistance. Furthermore, L. acidophilus IDCC 3302 was demonstrated to be nontoxic in the oral toxicity test in rats. Therefore, the results suggested that L. acidophilus IDCC 3302 might be safe for human consumption. © 2021, The Korean Society for Microbiology and Biotechnology
키워드
- 제목
- The in vitro and in vivo safety evaluation of lactobacillus acidophilus IDCC 3302
- 저자
- Bang, Wonyeong; Chae, Seung A.; Ban, O. Hyun; Oh, Sangki; Park, Chanmi; Lee, Minjee; Shin, Minhye; Yang, Jungwoo; Jung, Younghoon
- 발행일
- 2021
- 유형
- Article
- 저널명
- 한국미생물·생명공학회지
- 권
- 49
- 호
- 1
- 페이지
- 39 ~ 44
- 언어
- ENG
- 출판사
- Korean Society for Microbiolog and Biotechnology
- 분량
- 6 페이지
- ISSN
- E 223-4730
P 1598-642X