Establishment of iPSC (KRIBBi001-A) from CD34+ group O D-negative bone marrow blood

초록

Human induced pluripotent stem cells with indefinite propagation in vitro provide a potential donor source of cells including erythroid cells for human therapy. Since group O D-negative (RhD) blood cells are considered as universal donors for transfusion, it is compelling to derive iPSC line from group O/RhD sample as a new cellular source to generate universal RBCs. The resulting iPSC line derived from group O/RhD somatic source showed typical features of pluripotent stem cells and could provide an unprecedented cellular tool to develop universal therapeutics for blood transfusion.