Photonic interpenetrating polymer network intertwined with solid-state cholesteric liquid crystal and cationic polyelectrolyte networks for a skin-attachable sweat-based glucose biosensor

초록

A skin-attachable non-invasive biosensor film is developed using a photonic interpenetrating polymer network (IPN) intertwined with cholesteric liquid crystal (CLC) and poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) networks (photonic IPNPDMAEMA) for the determination of glucose levels in sweat. The cationic PDMAEMA polyelectrolyte network in the photonic IPNPDMAEMA immobilized with glucose oxidase (IPNPDMAEMAGOx) selectively catalyze the conversion of glucose to gluconic acid. This enzymatic reaction in the photonic IPNPDMAEMA-GOx reduces pH with a redshift in the photonic color of the CLC network. The photonic IPNPDMAEMAGOx film rests on a sweat-absorbing black substrate and is covered with a transparent medical-grade adhesive bandage to hold it in place and prevent sweat evaporation. The top bandage keeps the sensor hydrated until the photonic color change of the IPNPDMAEMA-GOx film saturates. The photonic IPNPDMAEMA-GOx film displays a redshift in response to glucose over a linear range of 0.2-6.0 mM with a limit of detection of 0.02 mM. The proposed cost-effective biosensor bandage is easy to manufacture, produces a rapid response with a small volume of sweat, and allows for visual detection without the use of sophisticated instruments. As such, it can be employed for real-time health monitoring and broadens the range of photonic sensor applications for cuttingedge wearable technology.

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