Human Breast Milk-Derived Extracellular Vesicles Enhance Osteoblast Activation via BMP2/MAPK Signaling Pathways

초록

Human breast milk-derived extracellular vesicles (HMEVs) have various physiological functions, includingimmune regulation, cell regeneration, and inflammation suppression, as well as potential therapeutic applications; however,research on the role of HMEVs in bone growth and bone remodeling is insufficient. This study examined the effects ofextracellular vesicles derived from human breast milk on osteoblast differentiation and mineralization and elucidated theirrole in the prevention and treatment of osteoporosis. The study’s results showed that HMEVs significantly enhance osteoblastproliferation, differentiation, and mineralization, as confirmed by increased expression of proteins and genes related tobone formation. These effects are mediated via the bone morphogenetic protein 2 (BMP2) and mitogen-activated proteinkinase (MAPK) signaling pathways. In other words, this study suggests that HMEVs may have a beneficial effect on the preventionand treatment of osteoporosis by promoting differentiation and mineralization of bone cells through the BMP2 andMAPK signaling pathways.

키워드