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The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
- El Bairi, Khalid;
- Haynes, Harry Russell;
- Blackley, Elizabeth F.;
- Fineberg, Susan A.;
- Shear, Jeffrey;
- ... Chaer, Yeesoo;
- 외 479명
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240초록
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC. © 2021, The Author(s).
- 제목
- The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
- 저자
- El Bairi, Khalid; Haynes, Harry Russell; Blackley, Elizabeth F.; Fineberg, Susan A.; Shear, Jeffrey; Turner, Sophia; De Freitas, Juliana Ribeiro; Sur, Daniel G.; Amêndola, Luis Claudio Belo; Gharib, Masoumeh; Kallala, Amine; Arun, Indu; Azmoudeh-Ardalan, Farid Amouzadeh; Fujimoto, Luciana; Sua, Luz Fernanda; Liu, Shiwei; Lien, Huangchun; Kirtani, Pawan; Balancin, Marcelo Luiz; El Attar, Hicham Abdelmalek; Guleria, Prerna; Yang, Wenxian; Shash, Emad; Chen, I. Chun; Bautista, Verónica Piña; do Prado Moura, José Fernando; Rapoport, Bernardo L.; Castañeda, Carlos Altamirano; Spengler, Eunice Amancay; Acosta-Haab, Gabriela; Frahm, Isabel; Sanchez, Joselyn; Castillo, Miluska; Bouchmaa, Najat; Md Zin, Reena Rahayu; Shui, Ruohong; Onyuma, Timothy; Yang, Wentao; Husain, Zaheed; Willard-Gallo, Karen E.; Coosemans, An; Perez, Edith A.; Provenzano, Elena; Ericsson, Paula González; Richardet, Eduardo; Mehrotra, Ravi Kumar; Sarancone, Sandra Isabel; Ehinger, Anna; Rimm, David L.; Bartlett, John M.S.; Viale, Giuseppe L.; Denkert, Carsten; Hida, Akira Iino; Sotiriou, Christos; Loibl, Sibylle; Hewitt, Stephen M.; BADVE, Sunil S.; Symmans, William Fraser; Kim, Rim S.; Pruneri, Giancarlo; Goel, Shom; Francis, Prudence A.; Inurrigarro, Gloria; Yamaguchi, Rin; García-Rivello, Hernán J.; Horlings, Hugo Mark; Afqir, Said; Salgado, Roberto A.; Adams, Sylvia; Kok, Marleen; Dieci, Maria Vittoria; Michiels, Stefan Phd; Demaria, Sandra; Loi, Sherene M.; de Freitas, Juliana Ribeiro; Lien, Huangchun; Denkert, Carsten; Symmans, William Fraser; Goel, Shom; Inurrigarro, Gloria; Demaria, Sandra; Schelfhout, Vera R.J.; Arbzadeh, Elham; Bondanar, Anastasiya; Bondanar, Anastasiya Antonio Galeano; Reyes, Silvio Antonio Galeano; Kang, Joon; Xiang, Lu; Zimovjanová, Martina; Togores, Pilar; Öztürk, Tülin Kılıçaslan; Patil, Asawari J.; Corpa, Marcus V.N.; Whitehouse, Ann L.; Tan, Benjamin Yongcheng; Batista De-Paula, Alfredo Maurício; Rossetti, Claudia; Lang-Schwarz, Corinna; Mahon, Sarah; Giacometti, Cinzia; Linderholm, Barbro K.; Deman, Frederik; Montagna, Giacomo; Gong, Gyungyub Yeop Yeop; Pavcovich, Marta; Chaer, Yeesoo; Cabrero, Isabel Alvarado; de Brito, Mayana Lopes; Ilieva, Nevena; Fulop, Annamaria; Souza, Maiara; Bilancia, Domenico; Idowu, Michael Ola; Johri, Ritika; Szpor, Joanna; Bachani, Lira; Schmitt, F. C.; Giannotti, Mag; Kurebayashi, Yutaka; Ramirez, Bruno Elias Anota; Salido, Eduardo C.; Bortesi, Laura; Bonetto, Sara; Elomina, Kevin; Lopez, Patricia; Sharma, Vijay; Edirisinghe, Amalika; Mathur, Dhanvi; Sahay, Ayushi; Mouloud, Makhlouf Ait; Giang, Chau Huynh; Mukolwe, Edwin; Kiruka, Edgar; Samberg, Nancy L.; Abe, Norie; Brown, Mark; Millar, Ewan K.A.; Li, Xiaoxian; Yuan, Zheng; Pasupathy, Asokan; Miele, Raffaele; Luff, Ronald D.; e Porfirio, Monica Modesto Araujo; Ajemba, Ogugua; Soni, Rashida; Orvieto, Enrico; DiMaio, Michael A.; Thomas, Jeremy; Merard, Reena; Subramaniam, Manish Mani; Apolinario, Thiago Lourenço; Preda, Ovidiu; Preda, Ricardo; Makanga, Alexander; Maior, Marcelo Souto; Li, Lingyu; Saghatchian, Mahasti; Saurine, Tricia J.; Janssen, Emiel A.M.; Cochran, John; Vlada, Nikitina; Cappellesso, Rocco; Elfer, Katherine Nicole; Hollick, Morven; Desai, Sangeeta B.; Oner, Gizem; Schreurs, Arthur; Liu, Steve; Perera, Rashindrie D.; Mercurio, Paola; García, Felip; Hosny, Kareem Mohammed; Matsumoto, Hirofumi; van Deurzen, Carolien H.M.; Bianchini, Giampaolo; Çoban, Ipek; Jahangir, Arif; Rahman, Arman; Stover, Daniel G.; Luz, Paulo Cesar Garcez Da Almeida; Martel, Anne L.; Waumans, Yannick; Stenzinger, Albrecht; Corteś, Javier; Dimitrova, Polina Damyanova; Nauwelaers, Inne; Velasco-Capellas, Montserrat; Akturk, Guray; Aktürk, Güray; Firer, Michael A.; Roxanis, Ioannis; Schneck, Mary; Wen, Hannah Yong; Cockenpot, Vincent; Konstantinov, Aleksei S.; Calatrava, Ana; Vidya, M. N.; Choi, Hyun-joo; Jank, Paul; ÇÏinen, Aini Hyyti; Sabanathan, Dhanusha; Floris, Giuseppe; Hoeflmayer, Doris; Hamada, Tetsuo; Laudus, Nele; Grigoriadis, Anita E.; Porcellato, Ilaria; Ács, Balázs; Miglietta, Federica; Parrodi, Jeannette; Clunie, David A.; Calhoun, Benjamin C.; Lu, Fang I.; Lefevre, Alex; Tabbarah, Sami; Tran, William Tyler; García-Murillas, Isaac; Jelinic, Petar; Boeckx, Carolien; Souza, Sandra C.; Cebollero, MarÇða Ç.; Felip, Eudald; Rendon, Jose Luis Solorzano; El-Gabry, Ehab A.; Saltz, Joel Haskin; Bria, Emilio; Garufi, Giovanna; Hartman, J.; Sebastian, Manu M.; Olofsson, Helena M.; Kooreman, Loes F.S.; Cucherousset, Joël; Mathieu, Marie Christine; Ballesteros-Merino, Carmen; Siziopikou, Kalliopi P.; Fong, Jacinta; Klein, Molly E.; Qulis, Ignasi Roig I.; Wesseling, Jelle; Bellolio, Enrique R.; Araya, J. C.; Naber, Stephen P.; Cheang, Maggie Chon U.; Castellano, Isabella; Ales, Ales; Laenkholm, Anne Vibeke; Kulka, Janina; Quinn, Cecily M.; Sapino, Anna; Amendoeira, Isabel; Marchiò, Caterina; Braybrooke, Jeremy P.; Vincent-Salomon, Anne; Korski, Konstanty; Sofopoulos, Michalis; Stovgaard, Elisabeth Specht; Biánchi, Simonetta; Bagó-Horváth, Zsuzsanna; Yu, Clare C.; Regitnig, Peter J.; Hall, Sean Ralph Robert; Kos, Zuzana; Sant, Sneha; Tille, Jean Christophe; Gallas, Brandon D.; Bethmann, Daniel; Savas, Peter S.; Mendes, Larissa; Soler, Teresa; van Seijen, Maartje M.; Gruosso, Tina; Quintana, Angela; Giltnane, Jennifer M.; van den Eynden, Gert G.G.M.; Duregon, Eleonora; de Cabo, Rafael C.; Recamo, Phil Coates; Gaboury, Louis Arthur; Zimmerman, Johannes; Pop, Claudia Stanciu; Wernicke, Alejandra; Williams, David; Gill, Anthony J.; Solomon, Benjamin J.; Thapa, Bibhusal; Farshid, Gelareh; Gilham, Leslie; Christie, Michael; O’Toole, Sandra A.; Hendry, Shona A.; Fox, Stephen B.; Luen, Stephen James; Lakhani, Sunil R.; Fuchs, Talia L.; John, Thomas; Brčić, Iva; Hainfellner, Johannes Andreas; Sigurd, Lax; Preusser, Matthias; Poortmans, Philip M.P.; Decaluwe, Alex; Carey, Caroline; Colpaert, Cécile G.A.; Larsimont, Denis P.; Peeters, Dieter J.E.; Broeckx, Glenn; van de Vijver, Koen K.B.T.; Buisseret, Laurence; Dirix, Luc Yves; Hertoghs, Marjan; Piccart, Martine J.; Ignatiadis, Michail Md Phd; Van Bockstal, Mieke R.; Sirtaine, Nicolas; Vermeulen, Peter B.; de Wind, Roland; Declercq, Sabine C.; Gevaert, Thomas; Haibe-Kans, Benjamin; Nelson, Brad H.; Watson, P. H.; Leung, Samuel C.Y.; Nielsen, Torsten O.; Shi, Leming; Balslev, Eva; Thagaard, Jeppe; Almangush, Alhadi; Måkitie, Antti Aarni; Joensuu, Heikki T.; Lundin, Johan E.; Drubay, Damien; Roblin, Elvire; André, Fabrice; Pénault-Llorca, Fréd́erique M.; Lemonnier, Jérôme; Adam, Julien; Lacroix-Triki, Magali; Ternès, Nils; Radosevic-Robin, Nina; Klaushen, Frederick; Weber, Karsten E.; Harbeck, Nadia; Gluz, Oleg; Wienert, Stephan; Cserni, Gábor; Vingiani, Andrea; Criscitiello, Carmen; Solinas, Cinzia; Curigliano, Giuseppe; Konishi, Eiichi; Suzuki, Eiji; Yoshikawa, Katsuhiro; Kawaguchi, Kosuke; Takada, Masahiro; Toi, Masakazu; Ishida, Mitsuaki; Ishida, Mitsuaki; Saji, Shigehira; Kogawa, Takahiro; Sakatani, Takashi; Okamoto, Takeru; Moriya, Takuya; Kataoka, Tatsuki R.; Shimoi, Tatsunori; Sugie, Tomohagu; Sugie, Tomohatru; Mukohara, Toru; Shu, Yazaki; Kikawa, Yuuichiro; Kozuka, Yuji; Sayed, Shahin; Rahayu, Reena; Ramsaroop, Reena; Senkus, Elżbieta; Chmielik, Ewa; Cardoso, Fatima; Ribeiro, Joana Mourato; Chan, Jack Junjie; Dent, Rebecca Alexandra; Martín, Miguel R.; Hagen, Carlos; Guerrero-Zotano, Ángel L.; Rojo, Federico; Comerma, Laura; Nucíforo, Paolo Giovanni; Serrano, Victor Vivo; Cámaea, Vincente Peg; Steenbruggen, Tessa Gerjanne; Ciompi, Francesco; Nederlof, Iris; van der Laak, Jeroen A.W.M.; van den Berg, José G.; Voorwerk, Leonie; Van De Vijver, Marc Joan; de Maaker, Michiel; Linn, Sabine C.; McKenzie, Hayley S.; Somaiah, Navita; Tutt, Andrew N.J.; Swanton, Charles; Hiley, Crispin T.; Moore, David Allan; Hall, Jacqueline A.; Le Quesne, John P.C.; Jabbar, Khalid Abdul; al-Bakir, Maise; Hills, Robert K.; Irshad, Sheeba; Yuan, Yinyin; Li, Zaibo; Liu, Minetta C.; Klein, Jonathan M.; Fadare, Oluwole; Thompson, Alastair Mark; Lazar, A. J.; Gown, Allen M.; Lo, Amy A.; Garrido-Castro, Ana Christina; Madabhushi, Anant; Moreira, Andre L.; Richardson, Andrea Lynn; Beck, Andrew H.; Bellizzi, Andrew M.; Wolff, Antonio C.; Harbhajanka, Aparna; Sharma, Ashish; Cimino-Mathews, Ashley Marie; Srinivasan, Ashok; Singh, Baljit; Chennubhotla, Chakra S.; Chauhan, Cynthia; Dillon, Deborah A.R.; Zardavas, Dimitrios; Johnson, Douglas B.; Thompson, E. Aubrey; Brogi, Edi; Reisenbichler, Emily S.; Huang, Erich; Hirsch, Fred R.; McArthur, Heather L.; Ziai, James M.; Brock, Jane E.; Kerner, Jennifer K.; Zha, Jiping; Lennerz K, Jochen K.; Carter, Jodi M.; Reis-Filho, Jorge Sérgio; Sparano, Joseph A.; Balko, Justin M.; Pogue-Geile, Katherine L.; Steele, Keith E.; Blenman, Kim R.M.; Allison, Kimberly Heller; Pusztai, Lajos; Cooper, Lee Alex Donald; Estrada, Valeria M.; Flowers, Margaret; Robson, Mark E.; Rebelatto, Marlon C.; Hanna, Matthew G.; Goetz, Matthew P.; Khojasteh, Mehrnoush; Sanders, Melinda E.; Regan, Meredith M.; Misialek, Michael J.; Amgad, Mohamed; Tung, Nadine M.; Singh, Rajendra S.; Huang, Richard S.P.; Pierce, Robert H.; Leon-Ferre, Roberto A.; Swain, Sandra M.; Ely, Scott A.; Kim, Seong-rim; Bedri, Shahinaz Ahmed; Paik, Soonmyung; Schnitt, Stuart J.; d’Alfons, Timothy; Kurkure, Uday; Bossuyt, Veerle Ilse Julie; Tong, Weida; Wang, Yihong; Dos Anjos, Carlos Henrique; Gaire, Fabien; van Diest, Paul J.
- 발행일
- 2021
- 유형
- Review
- 권
- 7
- 호
- 1
- 언어
- ENG
- 출판사
- Nature Research
- 발행국가
- 영국
- ISSN
- E 2374-4677