Peptide/Antibody-Drug Conjugates for Therapeutic Applications in Inflammatory Disease

초록

Peptide/antibody-drug conjugates (PADCs) are an emerging class of targeted therapeutics that leverage the specificity of peptide or antibody ligands to deliver potent small-molecule payloads selectively to disease sites via cleavable linkers. This design combines high target affinity with controlled local activation and minimal systemic toxicity. To date, 15 antibody-drug conjugates and 3 peptide-drug conjugates have been approved by the FDA; however, all are indicated exclusively for oncology. Consequently, the development of PADCs has primarily focused on cancer, with relatively few comprehensive reviews addressing their potential in non-oncological applications. In this review, the therapeutic potential of PADCs as a targeted strategy for treating inflammatory diseases-such as inflammatory bowel disease, chronic kidney inflammation, and arthritis-is explored by detailing how engineered peptide or antibody ligands recognize upregulated pathological markers in inflamed microenvironments and enable site-specific drug release through stimuli-responsive linkers. By consolidating recent advances, this review broadens the therapeutic scope of PADCs and highlights their promise as next-generation immunomodulators for targeted treatment of inflammatory diseases.

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