뇌전증약을 복용 중인 뇌전증 환자에서 코로나바이러스감염증-19 치료제를 사용할 때 고려사항

Consideration for Coronavirus Disease 2019 Drug Treatment in Patients with Epilepsy on Antiepileptic Drugs
  • 변정익; 
  • 선우준상; 
  • 강경욱; 
  • 김근태; 
  • 김대영; 
  • ... 서종근; 
  • 외 8명

초록

Several medications are approved to treat coronavirus disease 2019 (COVID-19) in Korea including nirmatrelvir/ritonavir, remdesivir, and regdanvimab. There is potential drug-drug interaction between antiepileptic drugs (AEDs) and the medications used to treat COVID-19. Several AEDs such as phenytoin, carbamazepine, phenobarbital, and primidone are strong cytochrome P450 inducers and can inhibit the drugs used for COVID-19. Particularly, these drugs are contraindicated with nirmatrelvir/ritonavir (Paxlovid® ). There is a weaker drug-drug interaction between the AEDs and remdesivir. No significant interaction has been reported between the AEDs and molnupiravir. Pharmacokinetic interactions of the AEDs are important in effective management of COVID-19 in patients with epilepsy

키워드

COVID-19; Epilepsy; Anticonvulsants; Drug interactions
제목
뇌전증약을 복용 중인 뇌전증 환자에서 코로나바이러스감염증-19 치료제를 사용할 때 고려사항
제목 (타언어)
Consideration for Coronavirus Disease 2019 Drug Treatment in Patients with Epilepsy on Antiepileptic Drugs
저자
변정익; 선우준상; 강경욱; 김근태; 김대영; 김동욱; 김세윤; 김세희; 김우준; 문혜진; 박혜리; 서종근; 황경진; 서대원
발행일
2022-05
유형
Y
저널명
대한신경과학회지
권
40
호
2
페이지
121 ~ 126