In vitro antioxidant, anti-inflammation, whitening, and anti-wrinkle effects of phenolic compounds from Humulus japonicus in ulreung island

초록

Humulus japonicus is known to have health benefits, but little is known about its effect on skin health. In this study, we investigated the anti-oxidation properties and potential impact on skin health using Humulus japonicus extracted phenolic compounds. In anti-oxidation activity, DPPH and 2,2'-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cation decolorization radical decolorization activity of hot water and 70% ethanol extracted phenolic compounds were approximately 69.25, 81.65, and 97.97, 97.58% at 200 μg/mL, respectively. PF and TBARS was 1.14 PF, 1.11 PF and 92.85, 88.60% at 200 μg/mL, which were higher than hydroxytoluen. In skin health, Humulus japonicus ethanol extracted phenolic compounds at 50-200 μg/mL inhibited the activity of elastase and collagenase by 42.83 and 84.22%, which suggests a potential anti-wrinkle effect. For skin-whitening and anti-inflammation effect, tyrosinase and hyaluronidase activity were inhibited by 38.36 and 21.71% in ethanol extract. Our results showed that HJE has remarkable antioxidant, anti-wrinkle, whitening, and potential anti-inflammatory effects, which suggests its potential as a beneficial source for anti-skin aging.

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