Formal Synthesis of Sex Pheromone of Gypsy Moth (+)-Disparlure from L-(+)-Tartaric Acid

초록

A simple strategy for the formal synthesis of the sex pheromone of gypsy moth (+)-disparlure from L -(+)-tartaric acid is described herein. The key steps include the mono-esterification and regioselective ring -opening of an epoxide using a Grignard reagent. The strategy of conferring asymmetry using 2-butanone enables mono-esterification in high yield and reduces the number of steps. Subsequently, (+)-disparlure is synthesized via the regioselective ring opening of the epoxide.

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