Red Blood Cell Deformability and Distribution Width in Patients with Hematologic Neoplasms

초록

Background: Despite increasing evidence that red blood cell (RBC) deformability is impaired in pathologic condi-tions, little research has been done on RBC deformability in hematologic diseases. The authors measured RBC de-formability in patients with various hematologic diseases, including hematologic malignancies. Methods: A total of 568 patients who underwent bone marrow (BM) examination for initial diagnosis were enroll -ed. We collected the subjects ' age, gender, diagnosis of BM examination, and complete blood count results. The RBC deformability, which was quantified by an elongation index, was measured by a microfluidic ektacytometer. Results: RBC deformability was lower in primary myelofibrosis, acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), chronic myeloid leukemia (CML), and acute lymphoblastic leukemia (ALL) from least to great -est. When the correlation between red blood cell distribution width (RDW) and RBC deformability was analyzed for 370 subjects in hematologic neoplasms, the correlation coefficient of RDW was-0.2974 (p < 0.01). When com-paring MDS and aplastic anemia (AA), the deformability of MDS was significantly lower than that of AA. Conclusions: RBC deformability was decreased in leukemic diseases such as AML, MDS, CML, and ALL com-pared to control, and RDW showed a negative correlation with deformability. RBC deformability may be used as a complementary differential diagnostic test for MDS and AA.

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