Disease Progression and Treatment of Mammary Gland Osteosarcoma in a Dog: A Case Report

초록

A 12-year-old intact female Miniature Pinscher dog was presented to our hospital with a large mass in the right mammary gland. On computed tomography, several masses throughout the mammary glands and enlarged bilateral inguinal lymph nodes were confirmed. Right hemimastectomy was performed first, and mammary gland osteosarcoma with lymph node metastasis was diagnosed by histopathological examination. After consultation with the owner, left hemimastectomy was not performed, but chemotherapy with carboplatin was initiated. The dog was treated with carboplatin, a tyrosine kinase inhibitor, and mega-dose vitamin C therapy for approximately eight months. However, during the course of treatment, pulmonary metastasis, neurological signs, and periosteal reaction in the appendicular skeletons developed, and the patient died after several seizure episodes. This present case report describes the overall disease progression and treatment of mammary gland osteosarcoma in a dog.

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