Emerging Perspectives of YAP/TAZ in Human Skin Epidermal and Dermal Aging

초록

Yes -associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key downstream effectors of the Hippo signaling pathway, which plays a central role in tissue homeostasis, organ development, and regeneration. While the dysregulation of YAP/TA Z has been linked to various human diseases, their involvement in the aging of human skin has only recently begun to manifest. In the skin, the YAP/TA Z effectors emerge as central regulators in maintaining homeostasis of epidermal stem cells and dermal extracellular matrix, and thus intimately linked to skin aging processes. This review underscores recent molecular breakthroughs highlighting how age -related decline of YAP/TA Z activity impacts human epidermal and dermal aging. Gaining insight into the evolving roles of YAP/TA Z in human skin aging presents a promising avenue for the development of innovative therapeutic approaches aimed at enhancing skin health and addressing age -related skin conditions.

키워드