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Synthesis and photodynamic effect of 3-substituted methyl pyropheophorbide-a derivatives as novel photodynamic therapeutic agents for cancer treatment
- Lee, Tae Heon;
- Kim, Hye Jeong;
- Lee, Bo-Ra;
- Lee, Sang Bong;
- Lee, Da-Sol;
- ... Kim, Kil Soo;
- 외 6명
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5초록
The unique ability of chlorophyll derivatives to accumulate in tumor tissues and cause a photodynamic effect under laser radiation has been successfully used in photodynamic therapy (PDT). Previous research on modified peripheral substituents in chlorophyll showed that the presence and position of substituents in chlorin derivatives remarkably affect biological activities. Herein, we synthesized methyl pyropheophorbide-a (MPPa) derivatives, which are chlorophyll-a derivatives with heterocyclic aromatic substituents or pyrazole moieties on the peripheral positions. Then, we examined the PDT effects of these new derivatives in vitro and in vivo. (c) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
키워드
- 제목
- Synthesis and photodynamic effect of 3-substituted methyl pyropheophorbide-a derivatives as novel photodynamic therapeutic agents for cancer treatment
- 저자
- Lee, Tae Heon; Kim, Hye Jeong; Lee, Bo-Ra; Lee, Sang Bong; Lee, Da-Sol; Han, Ye Ri; Kim, Kil Soo; Song, Young Kyu; Shim, Young Key; Park, Su-Jin; Kim, Dong-Won; Jeon, Yong Hyun
- 발행일
- 2022-01-25
- 유형
- Article
- 권
- 105
- 페이지
- 513 ~ 519
- 언어
- ENG
- 출판사
- ELSEVIER SCIENCE INC
- 발행국가
- 미국
- 분량
- 7 페이지
- ISSN
- E 1876-794X
P 1226-086X