A Study of the Biological Activity of Tillandsia ionantha Extracts in LPS-Induced RAW 264.7 Cells; LPS로 유도된 대식세포에서 틸란드시아 이오난사(Tillandsia ionantha) 추출물의 생리활성 탐색

초록

This study aimed to study the antioxidant and anti-inflammatory potential of Tillandsia ionantha, as a natural material by studying various physiological effects. T. ionantha is known for its strong anti-cancer activity and a high moisture absorption ability. T. ionantha was distilled with hot water (TID) and 70% ethanol (TIE) to obtain the relevant extracts. These extracts showed excellent antioxidant effects in terms of their electron-donating ability and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity. After measuring the cell viability of the TID, TIE extracts, and indomethacin in RAW 264.7 cells, subsequent experiments were conducted. At a concentration of 500 μg/mL, TID and TIE extract inhibited nitric oxide production, by 23.09% and 25.74%, respectively. It was also confirmed that TID and TIE extracts decreased the expression of PGE2 and TNF-α in a concentration-dependent manner. Both TID and TIE extracts decreased the expression of inducible nitric oxide synthase and cyclooxygenase 2. Therefore, the results of this study confirmed that the TID and TIE extracts have antioxidant and anti-inflammatory effects and have a high potential for use as natural materials for these purposes. © 2024 The Korean Society of Food Science and Nutrition.

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