Protection of Ducks Against Highly Pathogenic H5Nx Avian Influenza Viruses by HA Cleavage Site Peptide Vaccine

초록

Highly pathogenic H5Nx avian influenza viruses are endemic in animals in many countries. These viruses cause the severe diseases in chickens, but they cause much milder diseases in ducks. The vaccination is one of the tools to prevent the infections of ducks by highly pathogenic H5Nx avian influenza viruses. Here, we studied the efficacy of oil-adjuvanted H5 cleavage peptide vaccine in ducks. The vaccinated ducks challenged with H5N6 and H5N8 avian influenza viruses were protected without viral detection in the tracheal and cloacal swabs. The protective immunity in the immunized ducks lasted until 16 weeks post-vaccination. Our results suggest that H5 cleavage site peptide vaccine can be one of the candidate vaccines to provide the protective immunity to ducks against H5Nx avian influenza viruses.

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