Urease inhibition and anti-leishmanial properties of Zn(II) complexes of thiophenyl and furyl-derived C2-symmetric ligands

초록

A series of Zn(II) complexes (1-4) supported by thiophenyl- and furyl-derived N,N-diamines ligands, L-1-L-4, where L-1 = 2,2-dimethyl-N-1,N-3-bis(thiophen-2-ylmethyl)propane-1,3-diamine, L-2 = N-1,N-3-bis(thiophen-2-ylmethyl)propane-1,3-diamine, L-3 = N-1,N-3-bis(furan-2-ylmethyl)-2,2-dimethylpropane-1,3-diamine, and L-4 = N-1,N-3-bis(furan-2-ylmethyl)propane-1,3-diamine, were synthesized and characterized. Structural studies of 2 and 4 revealed a distorted tetrahedral geometry around the Zn(II) center. The synthesized ligands and their corresponding Zn(II) complexes were tested in vitro for urease inhibitory potential against Jack bean urease (JB urease) and Bacillus pasteurii urease (BP urease). Complex 2, possessing a thiophenyl pendant moiety, exhibited considerable inhibitory potential against JB urease (IC50 = 5.5 +/- 0.15 mu M) and BP urease (IC50 = 6.0 +/- 0.12 mu M) relative to the standard thiourea (IC50 = 10 +/- 0.52 and 8.20 +/- 0.90 mu M, respectively). Additionally, molecular docking confirmed the probable binding modes of the active complexes in the crystal structure of the JB urease. The synthesized ligands and complexes were also screened for anti-leishmanial activity and were proven to be effective against the Leishmania parasite.

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