Development of an Animal Stereotactic Device for Preclinical Research on Tumor Response After Stereotactic Radiosurgery

초록

BACKGROUND: In gamma knife radiosurgery, the tumor response to radiation is an important predictor of clinical treatment results. Since brain tumors have different char-acteristics and growth patterns, depending on the type, the tumors' response to radiation are also different. Compared with various other clinical treatments, there is a dearth of research on the development of gamma knife-magnetic resonance imaging (MRI) preclinical experimental equip-ment. Hence, the identification of preclinical equipment necessity for experimental animals will provide meaning-ful data for the provision of clinical assistance to humans.OBJECTIVES: A device for stereotactic radiosurgery capable of MRI in small animals was developed. The feasibility of creating a preplan by means of small animal images was then assessed.METHODS: A device for stereotaxic surgery of small animals using a 48-channel MRI coil was developed using a 3 dimensional printer. Rat brain-MRI images were ob-tained with a 3.0 T MRI scanner using a multi-channel coil. The acquired MRI images were transferred to a Gamma -Plan workstation to establish a preplan.RESULTS: To gamma rays to the targeted site on animals, a positioning device combined with a G-frame was mounted on a gamma knife. Planning of radiosurgery based on MRI images became possible with GammaPlan workstations.CONCLUSIONS: Preclinical experiments using small animals are possible with the use of stereotactic devices. In clinical treatment, preclinical experimental results will provide meaningful information.

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