Characteristics Control of Phytoncide-containing Copoly(Styrene-Acrylic Acid) Nanoparticles by Layer-by-Layer Assembly Method

초록

Mean particle size, colloidal stability, and release profile of copoly(styrene-acrylic acid) nanoparticles were controlled by layer-by-layer (LbL) assembly method using chitosan (CS) and carboxy methylcellulose (CMC) aqueous solutions. From FTIR analysis, successful layer assembly of CS and CMC was confirmed. Optimum conditions of LbL assembly was also confirmed by scanning electro microscopy (SEM) and particle size analyzer (PSA) analyses. Colloidal stability was evaluated by measuring zeta potential of particles. Release profile of core material (phytoncide oil) was measured by using UV-Vis spectrophotometer and high performance liquid chromatography (HPLC). (St-AA)NP prepared by miniemulsion copolymerization shows mean particle size and zeta potential of 351.0 nm and-39.77 mV, respectively. Mean particle size of LbL assembled particles can be controlled from 351 nm to 2,803 nm by optimization of LbL assembly conditions. Zeta potential values above +/- 40 mV evidence the coilloidal stability of particles. LbL assembled particles show controlled release profiles of phytoncide oil over 2 months.

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