Synthesis and characterization of ZnO/MgO nanocomposites: Targeted drug delivery strategies for cancer treatment

초록

Bimetallic oxide nanocomposites have emerged as promising candidates for anticancer applications due to their unique physicochemical properties, including high surface area, structural tunability, and well-organized structures, making them highly suitable for drug delivery systems. In this study, we present the green synthesis of bimetallic zinc oxide/magnesium oxide nanocomposites (ZnO/MgO-NCs) using the aqueous extracts of seaweed Turbinaria conoides as the reducing agent. The synthesized ZnO/MgO-NCs were comprehensively characterized at room temperature using UV-visible spectroscopy, X-ray diffraction (XRD), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX), and Fourier-transform infrared (FT-IR) spectroscopy. FT-IR spectra confirmed the presence of diverse functional groups associated with the nanocomposite, while the elemental analysis revealed characteristic peaks of zinc and oxygen, along with a minor signal corresponding to magnesium. Biological evaluations demonstrated the cytotoxicity potential of ZnO/MgONCs against U87 glioblastoma cells and their antimicrobial activity against Escherichia coli and Staphylococcus aureus. These findings highlight the potential of ZnO/MgO-NCs as multifunctional nanomaterials for future applications in anticancer drug delivery and antimicrobial therapy.

키워드