Synthesis, Characterizations, and 9.4 Tesla T2 MR Images of Polyacrylic Acid-Coated Terbium(III) and Holmium(III) Oxide Nanoparticles

초록

Polyacrylic acid (PAA)-coated lanthanide oxide (Ln(2)O(3)) nanoparticles (NPs) (Ln = Tb and Ho) with high colloidal stability and good biocompatibility were synthesized, characterized, and investigated as a new class of negative (T-2) magnetic resonance imaging (MRI) contrast agents at high MR fields. Their r(2) values were appreciable at a 3.0 T MR field and higher at a 9.4 T MR field, whereas their r(1) values were negligible at all MR fields, indicating their exclusive induction of T-2 relaxations with negligible induction of T-1 relaxations. Their effectiveness as T-2 MRI contrast agents at high MR fields was confirmed from strong negative contrast enhancements in in vivo T-2 MR images at a 9.4 T MR field after intravenous administration into mice tails.

키워드