The Immune Enhancement Effect of Pinus densiflora Pollen Extract in Splenocytes and Peritoneal Macrophages Derived from Naïve BALB/c Mice; Naïve BALB/c Mice에서 유래한 비장세포와 복강 대식세포에서 송화가루 추출물(Pinus densiflora Pollen Extract)의 면역 증강 효과

초록

COVID-19, SARS, and MERS were declared pandemic and are all infectious diseases caused by a virus. The innate immune system is important for preventing such infectious diseases. Therefore, this study examined the effects of Pinus densiflora pollen extract (PDE) on improving innate immunity. Pinus densiflora pollen is a natural micronutrient reservoir rich in various amino acids, vitamins, minerals, enzymes, and flavonoids required by the body. This study used splenocytes and peritoneal macrophages derived from BALB/c mice. PDE enhanced nitric oxide production in peritoneal macrophages. PDE alleviated dexamethasone (DEX)-induced reduction of splenocyte proliferation in concanavalin A (Con A)-stimulated splenocytes. PDE alleviated the DEX-induced reduction of interleukin-6, interleukin-1β, and tumor necrosis factor-α production in Con A-stimulated splenocytes. These results indicate that PDE can be a health-functional food material that improves immunity. © 2024 The Korean Society of Food Science and Nutrition.

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