Synthesis and application of N-3,5-dinitrobenzoyl and C3 symmetric diastereomeric chiral stationary phases

초록

Three diastereomeric chiral compounds, namely, (R,R)-(+)-2-amino-1,2-diphenylethanol, (1S,2R)-(+)-2-amino-1,2-diphenylethanol, and (1R,2R)-(+)-1,2-diphenylethylenediamine were used as starting materials for preparing three N-3,5-dinitrobenzoyl derivative chiral stationary phases (CSPs) (CSP 1, 2, and 3) and three C-3 symmetric CSPs (CSP 4, 5, and 6). The six newly prepared CSPs were applied to the chiral separation of 44 chiral samples by HPLC. Most samples were isolated on CSP 6, with the highest average separation factor among the six newly prepared CSPs.

키워드