Wnt/B-catenin signaling activator restores hair regeneration suppressed by diabetes mellitus

초록

Diabetes mellitus is one of the most prevalent diseases in modern society. Many complicationssuch as hepatic cirrhosis, neuropathy, cardiac infarction, and so on are associated with diabetes. Although a relationship between diabetes and hair loss has been recently reported, the treatment of diabetic hair loss by Wnt/B-catenin activators has not been achieved yet. In this study, we found that the depilation-induced anagen phase was delayed in both db/db mice and high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice. In diabetic mice, both hair regrowth and wound-induced hair follicle neogene-sis (WIHN) were reduced because of suppression of Wnt/B- catenin signaling and decreased proliferation of hair follicle cells. We identified that KY19382, a small molecule that acti-vates Wnt/B-catenin signaling, restored the capabilities of re-growth and WIHN in diabetic mice. The Wnt/B-catenin signal-ing activator also increased the length of the human hair fol-licle which was decreased under high glucose culture condi-tions. Overall, the diabetic condition reduced both hair regrowth and regeneration with suppression of the Wnt/B-catenin signal-ing pathway. Consequently, the usage of Wnt/B-catenin signaling activators could be a potential strategy to treat diabetes-induced alopecia patients. [BMB Reports 2022; 55(11): 559-564]

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