Inhibitory Effects of Tenebrio molitor Extract on Platelet Function and Thrombus Formation through Glycoprotein IIb/IIIa Suppression; 당단백질 IIb/IIIa 억제를 통한 혈소판 기능 및 혈전 형성에 대한 Tenebrio molitor 추출물의 억제 효과

초록

Platelets play fundamental roles in hemostasis and thrombosis, and antiplatelet drugs effectively reduce thrombosis in patients with cardiovascular disease. However, various side effects have been reported, and although various antiplatelet drugs have been developed, mortality rates of cardiovascular diseases have not decreased. Therefore, new antiplatelet drugs with fewer side effects are urgently required. This study examined whether Tenebrio molitor extract inhibits platelet aggregation by regulating integrin αIIb/β3 and its associated signaling molecules. Tenebrio molitor extract inhibited αIIb/β3 activation by regulating vasodilator-stimulated phosphoprotein, phosphatidylinositol-3 kinase, Akt, and glycogen synthase kinase-3α/β. In summary, Tenebrio molitor extract exhibited strong antiplatelet effects and appears to be a potential therapeutic for preventing platelet-related thrombosis and cardiovascular disease. © 2024 The Korean Society of Food Science and Nutrition.

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