미세가공 기술 기반의 마이크로니들 어레이 개발 및 패럴린 적용 가능성에 관한 연구

초록

In this research, we studied the development of a SUS304 microneedle array based on microfabrication technology and the applicability of Parylene-C thin film, a medical polymer material. First of all, four materials com- monly used in the field of medical engineering (SUS304, Ti, PMMA, and PEEK) were selected and a 5 μm Parylene- C thin film was deposited. The applicability of Parylene-C coating to each material was confirmed through SEM anal- ysis, contact angle measurement, surface roughness(Ra) measurement, and adhesion test according to ASTM stan- dards for each specimen. Parylene-C thin film was deposited based on chemical vapor deposition (CVD), and a 5 μm Parylene-C deposition process was established through trial and error. Through characteristic experiments to confirm the applicability of Parylene-C, SUS304 material, which is the easiest to apply Parylene-C coating without pretreat- ment was selected to develop a microneedle array based on CNC micromachining technology. The CNC microma- chining process was divided into a total of 5 steps, and a microneedle array consisting of 19 needles with an inner diameter of 200 μm, an outer diameter of 400 μm, and a height of 1.4 mm was designed and manufactured. Finally, a 5 μm Parylene-C coated microneedle array was developed, which presented future research directions in the field of microneedle-based drug delivery systems.

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