비경련뇌전증지속상태로 발현된 메토트렉세이트유발백질뇌병증

초록

Methotrexate (MTX) is an anti metabolite used in the treatment of leukemia and autoimmune disease. Careful observation of MTX concentration should be performed as side effects such as seizure, headache, limb paralysis, and confusion are found in MTX induced leukoencephalopathy. To our knowledge, there was no reported case of non convulsive status epilepticus as a manifestation of MTX induced leukoencephalopathy in South Korea. Here, we report a 54 year old patient that was diagnosed with non convulsive status epilepticus after long term use of MTX.

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