Groebke-Blackburn-Bienayme Reaction for DNA-Encoded Library Technology

An, Yujin; Lee, Juyeon; Seo, Hyewon; Bae, Seri; Kang, Jihee; Lee, Jieon; Kim, Jinwoo; Nam, Myung Hee; Song, Minsoo; Hwang, Gil Tae

doi:10.1021/acs.orglett.3c01366

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Groebke-Blackburn-Bienayme Reaction for DNA-Encoded Library Technology

An, Yujin;
Lee, Juyeon;
Seo, Hyewon;
Bae, Seri;
Kang, Jihee;
... Hwang, Gil Tae;
외 4명

Citations

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21

Citations

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21

초록

This study presents a DNA-compatible synthesis of diverse 5-arylimidazo[1,2-a]pyridin-3-amine derivatives using the Suzuki-Miyaura reaction, followed by a Groebke-Blackburn-Bienayme (GBB) reaction. The GBB reaction demonstrates a wide substrate scope, mild one-pot reaction conditions, and compatibility with subsequent enzymatic ligation, highlighting its potential in DNA-encoded library technology.

키워드

CHEMICAL LIBRARIES; SELECTION; DESIGN

제목: Groebke-Blackburn-Bienayme Reaction for DNA-Encoded Library Technology

저자: An, Yujin; Lee, Juyeon; Seo, Hyewon; Bae, Seri; Kang, Jihee; Lee, Jieon; Kim, Jinwoo; Nam, Myung Hee; Song, Minsoo; Hwang, Gil Tae

DOI: 10.1021/acs.orglett.3c01366

발행일: 2023-06-13

유형: Article

저널명: Organic Letters

권: 25

호: 24

페이지: 4445 ~ 4450

언어: ENG

출판사: AMER CHEMICAL SOC

발행국가: 미국

분량: 6 페이지

ISSN: E 1523-7052
P 1523-7060