Magnolia denudata desr. seed extract ameliorates oxidative stress-induced damage through heme oxygenase-1 activation in murine myoblasts

초록

This study examines the potential protective effects of Magnolia denudata Desr. seed extract (MSE) against oxidative stress in C2C12 myoblasts. MSE treatment improved cell survival under hydrogen peroxide (H2O2)-induced stress and reduced apoptotic markers. It also exhibited antioxidant properties by suppressing intracellular ROS accumulation and modulating key regulatory pathways. Notably, MSE enhanced the expression of heme oxygenase-1 (HO-1) through Nrf2 activation, suggesting its involvement in cellular defense mechanisms. These results indicate that MSE may serve as a functional material for mitigating oxidative stress-related muscle deterioration.

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