Synthesis of Double Benzimidazole-Fused Quinazolines and Pyrimidines Catalyzed by Recyclable Magnetic Cu-MOF-74

초록

2-(2-Bromoaryl)- and 2-(2-bromovinyl)benzimidazoles are combined and cyclized with benzimidazoles using a catalytic amount of magnetic Cu-MOF-74 (Fe3O4@SiO2@Cu-MOF-74) and a base under O2 atmosphere, yielding the corresponding double benzimidazole-fused quinazolines and pyrimidines. The catalyst can be recovered using a magnetic bar and reused multiple times without significant loss of catalytic activity. The reaction mechanism likely involves the initial formation of a C-N coupled intermediate through nucleophilic aromatic substitution, followed by oxidative cyclization.

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