Controversies in the Hypoxic Uptake Mechanism of Copper(II) diacetyl-di(N4-methylthiosemicarbazone): An Updated Review

초록

Cu(II) diacetyl-di(N4-methylthiosemicarbazone), also known as Cu(II)-ATSM, is a popular copper-complexed thiosemicarbazone derivative that has been widely studied for hypoxia. [64Cu]Cu-ATSM has emerged as an effective tracer for positron emission tomography imaging to functionally characterize hypoxic tumors. However, understanding the precise mechanism of cellular uptake and metabolism of Cu(II)-ATSM remains a controversial task in which different hypotheses have been proposed. Herein, we will elucidate the current findings regarding the hypoxic uptake mechanism of Cu(II)-ATSM. Particularly, we will investigate the cell internalization mechanism and intracellular reduction of Cu(II)-ATSM.

키워드