Antidiabetic activity of polysaccharide from Hypsizygus ulmarius in streptozotocin-nicotinamide induced diabetic rats

초록

The antibiotic potential of hot water extracted polysaccharide from Hypsizygus ulmarius (HUP) in streptozotocinnicotinamide (STZ-NA) induced diabetes was assessed. Dose-dependent supplementation of the HUP (200 and 400 mg/kg of body weight) resulted in a reduction in body weight, fasting blood glucose, hepatic function, kidney function, serum lipid metabolism, lipid peroxidation, and an increase in insulin levels, glycogen storage and antioxidant enzyme activities, contributing to its effective hypoglycemic benefits, in comparison with STZinduced diabetic rats. The results were compared to glibenclamide, which was used as a positive control. HUP was also observed to possess concentration-dependent moderate inhibition activity against alpha-amylase and alpha-glucosidase enzymes. This investigation showed that the HUP has a potential antidiabetic effect both in vitro and in vivo. In conclusion, it can be stated from the findings that HUP possesses immense potential, as a functional food, as well as a replacement for diabetic medication in the treatment of diabetes mellitus and its consequences.

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