Synthesis of Fluorophores with Aggregation-induced Emission Characteristics Using Fluorescein Derivatives

초록

In this research, novel AIE (Aggregation-Induced Emission) fluorophores were synthesized by ingeniously attaching a variety of substituents, including allyl, benzyl, and propargyl groups, to the hydroxy and carboxylate groups of fluorescein. The findings revealed a fascinating trend: the fluorescence intensity of these compounds varied progressively with the solvent ratio. This intriguing behavior is attributed to the superior aggregation of the synthesized materials in aqueous environments compared to organic solvents, resulting in markedly enhanced fluorescence. Moreover, the optical characteristics of these materials were found to be significantly influenced by the specific type of substituent grafted onto the fluorescein backbone. Notably, the fluorescence intensity was observed to escalate in the sequence of methoxy triethylene glycol, azidoethyl, allyl, propargyl, and benzyl group in the solution of H2O:DMSO (=99:1). The implications of this study can be vast, particularly in the realm of fundamental research areas like molecular imaging and sensor technology. These innovative AIE fluorophores offer a promising platform for advanced applications, leveraging their unique fluorescence behav ior dictated by the nature of the substituent and the solvent environment.

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