Bioactive Surface of Zirconia Implant Prepared by Nano-Hydroxyapatite and Type I Collagen

초록

Zirconia, with its excellent mechanical strength and esthetics, has a growing potential for applications in dentistry and orthopedics. However, in order for zirconia to have a high affinity with bone tissue, the bioactivity of the surface must be further increased. In order to increase the bioactivity of zirconia, research was conducted to make a porous support or to fill the porous structure with nano-hydroxyapatite (nHA). In this case, there is a risk that physically filled nHA could be released depending on the living environment. In this study, nHA and type I collagen were introduced to the zirconia surface by chemical covalent bonding to increase bioactivity and ensure safety in the body. The chemical reaction of the surface was confirmed by X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FE-SEM) and Fourier transform infrared (FT-IR) spectroscopy. In addition, the biological activity was evaluated by examining the cytotoxicity and bone formation ability of the modified zirconia using osteoblasts. As a result, it was found that the bioactivity of the zirconia surface was greatly improved by immobilizing nHA and type I collagen.

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