Zwitterionic neurotransmitter-sensitive gadolinium complex as a potential MRI contrast agent for Alzheimer's disease diagnosis

초록

An imbalance in neurotransmitters (NTs) is associated with the progression of Alzheimer's disease (AD). Glutamate (Glu), a zwitterionic NT, is strongly associated with AD and is highly concentrated in the brain. Therefore, Glu is a good target for the diagnosis of AD using magnetic resonance imaging (MRI). In the current study, we synthesized a gadolinium-based MR contrast agent (Gd-crown) that could detect Glu. Relaxivity measurements showed that Gd-crown has selectivity for zwitterionic NTs including Glu. Furthermore, Gd-crown was successfully used to monitor MRI signal differences between APP/PS1 transgenic AD mice and normal mice according to the concentrations of Glu in MRI experiments in vivo. (c) 2022 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

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