The inhibitory effects of Ampelocissus martinii Planch. extract on LPS-induced inflammation and oxidative stress in RAW 264.7 cells

초록

Chronic inflammation contribute to the development of Crohn’s disease and ulcerative colitis and cancer. This study focused on evaluating the anti-inflammatory and antioxidant effects of Ampelocissus martini Planch. extract (AME) in RAW264.7 cells. AME significantly suppressed lipopolysaccharide (LPS)-induced nitric oxide production and inducible nitric oxide synthase expression in RAW264.7 cells. AME also significantly suppressed LPS-induced tumor necrosis factor-α mRNA expression and phosphorylatioin of Jun N-terminal kinase. In addaition, AME significantly suppressed LPS-induced reactive oxygen species production in RAW264.7 cells. Also, AME had ABTS and DPPH radical scavenging capacity as much as ascorbic acid known as antioxidants. The results of study suggest that AME can be health functional food material with antiinflammatory and antioxidant effects.

키워드