Overview of the characterization of extracellular vesicles

초록

Extracellular vesicles (EVs) are a captivating domain in cell biology, reshaping our understanding of intercellular communication. Initially dismissed as debris, EVs are now vital mediators in physiological and pathological processes. This chapter provides a comprehensive overview of EV research, spanning background, significance, biological diversity, characterization methods, challenges, and prospects. Characterizing EVs is crucial due to their diverse cargo, which is essential for biomedical applications. Their potential as diagnostic tools and therapeutics is emphasized. Biological diversity is explored, categorizing EVs into subtypes and elucidating their origin and roles. The chapter outlines methods for EV characterization, including isolation and physical techniques, and also discusses molecular profiling methods. Moreover, it covers the promise of innovation and collaboration to overcome challenges in EV research, leading to breakthroughs and advancing disease diagnosis and treatment through personalized medicine using EVs. © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

키워드